D-dimer was the degradation products of cross linked fibrin, which made by the fibrinogen in the human plasma in the common work of fibrinogen thrombin, Factor XIIIa and calcium ions and degraded by fibrinolytic enzyme.
In recent years, the clinical diagnostic value has been recognized widely since D–dimmer become the Characteristic staples of the hydrolysed crosslinking fibre protein in vivo.
It has great Significance to measure the main factor D – dimmer in the fibrinolytic system ,which can help to diagnosis and treatment the diseases related to fibrinolytic system (such as DIC, all sorts of thrombosis), fibrinolytic system (such as cancer, pregnancy syndrome), and monitor therapy of thrombolysis.The rising level of D-dimer shows that there has been frequent fibrin degradation process in the body. Therefore, D - dimer is a key indicator of deep vein thrombosis (DVT) , pulmonary embolism (PE), and diffuse intravascular coagulation (DIC). D – dimmer demonstrates great values in clinical application depending on its high sensitivity and ability of negative predictor。