Human b-type natriuretic peptide (hBNP), or brain natriuretic peptide, is a 32–amino acid peptide produced primarily in the heart by the left ventricle . Endogenous hBNP levels are elevated in patients with HF and serve as a sensitive and specific serologic marker for left ventricular dysfunction ,prompting speculation that hBNP may play a role in the modulation of cardiac and vascular function and fluid status in this population . B-type natriuretic peptide (BNP) is synthesized in cardiomyocytes as the precursor form (proBNP 1-108) that is cleaved by a specific enzyme to form the physiologically active BNP (77-108) and inactive N-terminal proBNP (1-76, NT-proBNP).
B-type natriuretic peptide (BNP) and N-terminal pro BNP (NT-proBNP) are natriuretic peptides and serve as serum biomarkers for the diagnosis of heart failure . Despite being equally used for the diagnosis of heart failure, there are major differences including the plasma half-time, which is about 20 min for BNP and 25–70 min for NT-proBNP . In healthy subjects the plasma levels of NT-proBNP are higher than BNP-levels, and in patients with increased ventricular walls tress NT-proBNP rises more than BNP [5,7].
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